Endocrine Abstracts

Background: Diabetic retinopathy is a common complication of diabetes mellitus and the leading cause of blindness in the working-age population in the developed world. Novel biomarkers are needed to improve the screening efficiency for the prevention and early treatment of this condition. Accumulation of advanced glycation end products (AGEs) is considered as one of pathogenetic pathways in development of diabetic complications. AGEs are formed in the process of non-enzymatic ...

Background: Diabetic retinopathy (DR) is one of the most common complication of diabetes and it has a significant impact on national and global health. Accumulation of advanced glycation endproducts (AGE) is recognized as a contributing factor in the development of diabetic complications. The evaluation of AGE has the potential to be an important biomarker in DR, reflecting the impact of prolonged high glucose levels on long-term metabolic memory.Aim: Th...

BackgroundDiabetic retinopathy is the leading cause of blindness in working-age adults in developed world. Derangements of ubiquitine-proteasome system and telomere length have been associated with microangiopathy in diabetes. Until now, limited data are available on above markers in diabetic retinopathy in type 1 diabetes (T1D).AimThe aim of this work was to compare serum proteasome concentration and telomer...